Etomidate Powder – Product Overview
Etomidate is a carboxylated ester containing an imidazole ring, classified as a non‑barbiturate, ultrashort‑acting intravenous hypnotic agent. In its pure form, it appears as a white crystalline or crystalline powder. The molecular formula is C₁₄H₁₆N₂O₂, with a molecular weight of 244.29 and a CAS registry number of 33125‑97‑2.
Key Physicochemical Properties:
High Purity: As a pharmaceutical‑grade active pharmaceutical ingredient (API), our Etomidate powder meets stringent quality standards, with a purity of not less than 98.5% on the dried basis – and in many refined batches, exceeding 99.0%. The melting point ranges between 67 °C and 73 °C.
Superior Solubility: Etomidate is freely soluble in ethanol and chloroform, but practically insoluble in water. Owing to its lipophilic nature, it dissolves readily in injectable lipid vehicles such as medium‑chain triglycerides (MCT), making it an ideal component for intravenous lipid emulsion formulations.
Pharmacological Action: As an ultrashort‑acting anesthetic, Etomidate acts on the central nervous system by potentiating γ‑aminobutyric acid type A (GABAA) receptors, thereby enhancing chloride ion channel opening and producing rapid hypnotic and sedative effects. Upon intravenous administration, it induces anaesthesia within one arm‑brain circulation, with a notably favourable safety profile – minimal cardiovascular depression and respiratory depression, making it a preferred agent for anaesthesia induction in haemodynamically unstable patients.
Primary Application:
Etomidate powder serves as the essential raw material for the preparation of intravenous anaesthetic formulations used in general anaesthesia induction, outpatient surgery, short‑term procedural sedation, and intensive care settings. It is widely utilised in hospitals, ambulatory surgical centres, and emergency departments globally.